{"id":2669,"date":"2024-01-17T08:00:00","date_gmt":"2024-01-17T00:00:00","guid":{"rendered":"https:\/\/oepxsr.com\/?p=2669"},"modified":"2024-01-18T18:21:45","modified_gmt":"2024-01-18T10:21:45","slug":"%e4%b8%a4%e5%ba%a6%e7%99%bb%e9%a1%b6jama%e4%b8%bb%e5%88%8a%ef%bc%81%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%8d%95%e6%8a%97%e5%bb%ba%e7%ab%8b%e8%82%ba%e7%99%8c","status":"publish","type":"post","link":"https:\/\/oepxsr.com\/%e4%b8%a4%e5%ba%a6%e7%99%bb%e9%a1%b6jama%e4%b8%bb%e5%88%8a%ef%bc%81%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%8d%95%e6%8a%97%e5%bb%ba%e7%ab%8b%e8%82%ba%e7%99%8c\/","title":{"rendered":"\u4e24\u5ea6\u767b\u9876JAMA\u4e3b\u520a\uff01\u541b\u5b9e\u751f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\u5efa\u7acb\u80ba\u764c\u56f4\u624b\u672f\u671f\u6cbb\u7597\u65b0\u6a21\u5f0f"},"content":{"rendered":"\n<p>\u5f53\u5730\u65f6\u95f42024\u5e741\u670816\u65e5\uff0c\u7531\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u80f8\u79d1\u533b\u9662\u9646\u821c\u6559\u6388\u7275\u5934\u5f00\u5c55\u7684\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7528\u4e8e\u53ef\u5207\u9664\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u56f4\u624b\u672f\u671f\u6cbb\u7597\u7684\u2162\u671f\u7814\u7a76\uff08NEOTORCH\uff09\u83b7\u56fd\u9645\u9876\u5c16\u6743\u5a01\u671f\u520a\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u300b\uff08<em>Journal 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class=\"wp-element-caption\">\u6765\u6e90\uff1a<em>JAMA<\/em>\u5b98\u7f51<\/figcaption><\/figure>\n\n\n\n<p>NEOTORCH\u7814\u7a76\uff08NCT04158440\uff09\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u6bd4\u8f83\u7279\u745e\u666e\u5229\u5355\u6297\u6216\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7528\u4e8e\u53ef\u5207\u9664\u2161-\u2162\u671fNSCLC\u60a3\u8005\u56f4\u624b\u672f\u671f\u6cbb\u7597\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u4f5c\u4e3a<strong>\u5168\u7403\u9996\u4e2a<\/strong>\u6297PD-1\u5355\u6297\u7528\u4e8eNSCLC\u56f4\u624b\u672f\u671f\uff08\u6db5\u76d6\u65b0\u8f85\u52a9\u548c\u8f85\u52a9\u6cbb\u7597\uff09\u6cbb\u7597\u8fbe\u5230\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u9633\u6027\u7ed3\u679c\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff0cNEOTORCH\u57282023\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5168\u4f53\u5927\u4f1a\u7cfb\u52174\u6708\u4f1a\u8bae\u4ee5\u53caASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u2162\u671fNSCLC\u60a3\u8005\u7684EFS\u671f\u4e2d\u5206\u6790\u7ed3\u679c\uff0c\u83b7\u5f97\u56fd\u9645\u5b66\u8005\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u6b64\u6b21\u518d\u83b7\u5168\u7403\u6392\u540dTOP4\u7684SCI\u5b66\u672f\u671f\u520aJAMA\u53d1\u8868\uff0c\u4e5f\u8ba9<strong>\u7279\u745e\u666e\u5229\u5355\u6297\u6210\u4e3a\u9996\u4e2a\u4e24\u5ea6\u767b\u9876JAMA\u4e3b\u520a\u7684\u56fd\u4ea7PD-(L)1\u6291\u5236\u5242<\/strong>\u3002<\/p>\n\n\n\n<p><strong>NEOTORCH\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005\u9646\u821c\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201c\u4e0d\u8bba\u662f\u4e34\u5e8a\u8bca\u7597\u6c34\u5e73\u8fd8\u662f\u4e34\u5e8a\u79d1\u7814\u80fd\u529b\uff0c\u6211\u4eec\u5df2\u7ecf\u7531\u6b64\u524d\u7684\u2018\u8ddf\u8dd1\u8005\u2019\u9010\u6e10\u8f6c\u53d8\u4e3a\u2018\u540c\u884c\u8005\u2019\u751a\u81f3\u5728\u4e00\u4e9b\u65b9\u9762\u6210\u4e3a\u2018\u9886\u8dd1\u8005\u2019\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u4e2d\u56fd\u521b\u65b0\u65b9\u6848\u624e\u6839\u4e2d\u56fd\uff0c\u8d70\u5411\u4e16\u754c\uff0c\u5e76\u6700\u7ec8\u6539\u53d8\u5168\u7403\u6cbb\u7597\u6807\u51c6\u3002\u6b64\u6b21NEOTORCH\u83b7\u5f97JAMA\u53d1\u8868\u662f\u4e00\u4e2a\u8d77\u70b9\uff0c\u4e2d\u56fd\u539f\u521b\u7684\u20183+1+13\u2019\u56f4\u672f\u671f\u6cbb\u7597\u6a21\u5f0f\u5177\u6709\u6700\u9ad8\u5faa\u8bc1\u533b\u5b66\u4ef7\u503c\uff0c\u5fc5\u5c06\u4e3a\u60a3\u8005\u5efa\u7acb\u65b0\u7684\u6cbb\u7597\u6807\u51c6\uff0c\u4e3a\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u80ba\u764c\u8bca\u7597\u683c\u5c40\u5e26\u6765\u53d8\u9769\u3002\u201d<\/p>\n\n\n\n<p>\u4f5c\u4e3a\u76ee\u524d\u7eb3\u5165<strong>\u4e2d\u56fd\u6700\u5927\u6837\u672c<\/strong>\u53ef\u5207\u9664\u2162\u671fNSCLC\u60a3\u8005\u7684\u56f4\u624b\u672f\u671f\u524d\u77bb\u6027\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff0cNEOTORCH\u5171\u7eb3\u5165404\u4f8b\u2162\u671fNSCLC\u60a3\u8005\uff08\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4202\u4f8b\uff0c\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4202\u4f8b\uff09\uff0c\u4ee51:1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d7\u7279\u745e\u666e\u5229\u5355\u6297\u6216\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u672f\u524d3\u5468\u671f\u53ca\u672f\u540e1\u5468\u671f\u56f4\u624b\u672f\u6cbb\u7597\uff0c\u968f\u540e\u63a5\u53d7\u7279\u745e\u666e\u5229\u5355\u6297\u6216\u5b89\u6170\u5242\u5de9\u56fa\u6cbb\u759713\u5468\u671f\uff08\u5373\uff1a\u201c3+1+13\u201d\u6cbb\u7597\u6a21\u5f0f\uff09\u3002<\/p>\n\n\n\n<p>\u622a\u81f32022\u5e7411\u670830\u65e5\uff08\u4e2d\u4f4d\u968f\u8bbf18.3\u4e2a\u6708\uff09\uff0c\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5355\u72ec\u5316\u7597\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u56f4\u624b\u672f\u671f\u6cbb\u7597\u540e\u7279\u745e\u666e\u5229\u5355\u6297\u5355\u836f\u5de9\u56fa\u6cbb\u7597\uff0c\u53ef\u663e\u8457\u5ef6\u957f\u53ef\u5207\u9664\u2162\u671fNSCLC\u60a3\u8005\u7684EFS\uff0c\u660e\u663e\u63d0\u9ad8\u4e3b\u8981\u75c5\u7406\u7f13\u89e3\uff08MPR\uff09\u548c\u5b8c\u5168\u75c5\u7406\u7f13\u89e3\uff08pCR\uff09\u7387\u3002\u65e0\u8bba\u80bf\u7624\u5206\u671f\uff08\u2162A\u671f\u6216\u2162B\u671f\uff09\u3001\u7ec4\u7ec7\u4e9a\u578b\uff08\u9cde\u764c\u6216\u975e\u9cde\u764c\uff09\u53caPD-L1\u8868\u8fbe\u5982\u4f55\uff0cEFS\u5747\u53ef\u83b7\u76ca\uff0c\u540c\u65f6OS\u4e5f\u663e\u793a\u51fa\u660e\u663e\u7684\u83b7\u76ca\u8d8b\u52bf\uff0c\u5b89\u5168\u6027\u53ef\u9884\u671f\u3001\u53ef\u7ba1\u7406\u3002<\/p>\n\n\n\n<ul>\n<li>\u4e0e\u5355\u7eaf\u5316\u7597\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u663e\u8457\u5ef6\u957f\u60a3\u8005\u7684EFS\uff08\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u4e2d\u4f4dEFS\u4e3a\uff1a\u5c1a\u672a\u6210\u719f vs. 15.1\u4e2a\u6708\uff09\uff0c\u5c06\u75be\u75c5\u590d\u53d1\u3001\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e60%\uff08HR=0.40\uff1b95%CI\uff1a0.28-0.57)\uff0c\u53cc\u4fa7P&lt;0.001\u3002<\/li>\n\n\n\n<li>\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u7684MPR\u7387\u660e\u663e\u66f4\u4f18\uff0c\u662f\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\u76846\u500d\uff08\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u75c5\u7406[BIPR]\u8bc4\u4f30\u7684MPR\u7387\u5206\u522b\u4e3a48.5% vs. 8.4%\uff09\u3002\u540c\u65f6\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u7684pCR\u7387\u4e5f\u8f83\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\u63d0\u9ad8\u4e8625\u500d\uff08BIPR\u8bc4\u4f30\u7684pCR\u7387\u5206\u522b\u4e3a24.8% vs. 1.0%\uff09\u3002<\/li>\n\n\n\n<li>\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u663e\u8457\u6539\u5584\u60a3\u8005\u7684\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\uff0c\u5c06\u75be\u75c5\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e50%\uff08HR=0.50\uff1b95%CI: 0.33-0.76\uff09\uff0c\u5e76\u4e14\u7279\u745e\u666e\u5229\u5355\u6297\u7ec4\u6709\u660e\u663e\u7684OS\u83b7\u76ca\u8d8b\u52bf\uff08\u4e2d\u4f4dOS\u5206\u522b\u4e3a\uff1a\u5c1a\u672a\u8fbe\u5230 vs. 30.4\u4e2a\u6708\uff0cHR=0.62[95% CI: 0.38-1.00]\uff09\u3002<\/li>\n\n\n\n<li>\u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u540e\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u4e3a\u66f4\u591a\u60a3\u8005\u5e26\u6765\u4e86\u6839\u6cbb\u6027\u624b\u672f\u5207\u9664\u7684\u673a\u4f1a\uff0c\u624b\u672f\u5207\u9664\u7387\u5206\u522b\u4e3a82.2% vs. 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Lu S, Zhang W, et al. Perioperative Toripalimab Plus Chemotherapy for Patients With Resectable Non-Small Cell Lung Cancer: The Neotorch Randomized Clinical Trial. 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